Registration Dossier
Registration Dossier
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EC number: 433-460-1 | CAS number: 210880-92-5
Endpoint summary
Administrative data
Description of key information
DT50 = > 1 year, degradation in water recalculated to 12 °C
DT50 = 138 days, degradation in sediment recalculated to 12 °C
DT50 = 33 to 371 days, degradation in soil recalculated to 12 °C
Additional information
No study on ready biodegradability is available for (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine. However, since higher tier studies on the biodegradation of (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine in water, sediment and soil are available no additional study on ready biodegradability is necessary. The PBT assessment and environmental classification can be derived based on the available higher tier studies.
In a simulation study, the degradation of the target substance (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine in water at 20 °C, according to GLP and OECD Guideline 309, was found to be insignificant (DT50 > 1 year).
In a simulation study on the biodegradation in natural pond water/sediment systems revealed a half-life of the test substance of 138 days at 12 °C (recalculated from experimental data at 20 °C). After an incubation period of 100 days 14CO2 accounted for <5% of the initially applied radioactivity. The data generated within this study demonstrate the test substance to disappear rapidly from the supernatant water by dissipation. At the end of the incubation period (100 days) 28 to 43% of the applied radioactivity was present as non-extractable residues.
In soil, the target substance attained 9.4 to 29.3% degradation (elevation of 14CO2) after 120 days and 20 °C, and the half-life in soil was found to range from 9.7 to 174.6 days (33 to 371 days, recalculated to 12 °C).
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