Registration Dossier
Registration Dossier
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EC number: 433-460-1 | CAS number: 210880-92-5
Phototransformation in water
Administrative data
Link to relevant study record(s)
Description of key information
(E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine is photolytically degraded in water with an average half-life of 26.4 hours in natural river water and 3.3 hours in aqueous buffer solution at pH 7.
Key value for chemical safety assessment
- Half-life in water:
- 27.8 h
Additional information
The endpoint “phototransformation in water” is not a data requirement for the registered substance. However, for the sake of completeness this endpoint is covered by a short summary of the available data. There are a total of 2 studies on the phototransformation in water available. Both studies were performed under GLP conditions.
In the first study, the photolytic degradation of (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine was investigated in natural US river water. Under the experimental conditions used, the test substance was thoroughly degraded with an experimental half-life (DT50) of 25.to 27.8 hours.
The second study investigated the photolytic degradation of (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine in sterile aqueous buffer solution at pH 7. Under the experimental conditions used, the test substance degraded rapidly with an experimental half-life (DT50) of 3.3 hours (mean of two labels; 1st order rate constant = 0.2088 hr-1; r2 = 0.9895). The experimental half-life corresponds to a calculated environmental half-life of 0.6 days under midsummer solar light conditions e.g. at Phoenix/USA.
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