Registration Dossier
Registration Dossier
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EC number: 200-309-2 | CAS number: 57-06-7
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of a Three-Exposure Mouse Bone Marrow Micronucleus Protocol: Results with 49 Chemicals
- Author:
- M.D. Shelby, G.L. Erexson, G.J. Hook and R.R. Tice
- Year:
- 1 993
- Bibliographic source:
- Environmental and Molecular Mutagenesis 21: 160-179 (1993)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- Only a single sex was used.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Allyl isothiocyanate
- EC Number:
- 200-309-2
- EC Name:
- Allyl isothiocyanate
- Cas Number:
- 57-06-7
- Molecular formula:
- C4H5NS
- IUPAC Name:
- 3-isothiocyanatoprop-1-ene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Each chemical was prepared in the appropriate solvent (PBS for water soluble chemicals, corn oil for water-insoluble chemicals).
- Duration of treatment / exposure:
- Three consecutive day
- Frequency of treatment:
- Daily
- Post exposure period:
- 48 hr after the third treatment, the surviving mice were euthanized
Doses / concentrationsopen allclose all
- Dose / conc.:
- 37.5 mg/kg bw/day (nominal)
- Dose / conc.:
- 75 mg/kg bw/day (nominal)
- Dose / conc.:
- 150 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- Groups of 5 mice were administered the test chemicals.
- Control animals:
- yes
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- AITC did not increase the number of micronuclei in bone marrow cells.
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