Registration Dossier
Registration Dossier
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EC number: 200-309-2 | CAS number: 57-06-7
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- CARCINOGENESIS BIOASSAY OF ALLYLISOTHIOCYANATE (CAS NO. 57-06-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDY)
- Author:
- NATIONAL TOXICOLOGY PROGRAM
- Year:
- 1 982
- Bibliographic source:
- NTP-81-36 NIH Publication No. 83-1790
Materials and methods
- Principles of method if other than guideline:
- Thirteen-week studies were conducted to evaluate the cumulative toxicity of allyl isothiocyanate and to determine the doses to be used in the chronic studies.
Groups of 10 rats and mice of each sex received 1.5, 3, 6, 12, or 25 mg/ kg allyl isothiocyanate by gavage 5 days per week for 13 weeks. Vehicle controls received corn oil alone. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Allyl isothiocyanate
- EC Number:
- 200-309-2
- EC Name:
- Allyl isothiocyanate
- Cas Number:
- 57-06-7
- Molecular formula:
- C4H5NS
- IUPAC Name:
- 3-isothiocyanatoprop-1-ene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- other: F344/N rats and B6C3F1 mice
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- 13 weeks
Doses / concentrationsopen allclose all
- Dose / conc.:
- 1.5 mg/kg bw/day (nominal)
- Remarks:
- 5 days per week
- Dose / conc.:
- 3 mg/kg bw/day (nominal)
- Remarks:
- 5 days per week
- Dose / conc.:
- 6 mg/kg bw/day (nominal)
- Remarks:
- 5 days per week
- Dose / conc.:
- 12 mg/kg bw/day (nominal)
- Remarks:
- 5 days per week
- Dose / conc.:
- 25 mg/kg bw/day (nominal)
- Remarks:
- 5 days per week
- No. of animals per sex per dose:
- Groups of F344/N rats: 10 animals/sex/group
Groups of B6C3F1 mice: 10 animals/sex/group - Control animals:
- yes, concurrent vehicle
Examinations
- Observations and examinations performed and frequency:
- Animals were observed twice daily for mortality, morbidity and clinical signs of toxicity.
- Sacrifice and pathology:
- On days 92 to 96, all animals were killed and a necroscopy carried out.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Body weight and weight changes:
- no effects observed
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Remarks:
- rats
- Effect level:
- 25 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- gross pathology
- Key result
- Dose descriptor:
- NOAEL
- Remarks:
- mice
- Effect level:
- 25 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- gross pathology
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- No gross or microscopic lesions were seen at the highest dose level (25 mg/kg) in the 13-week study.
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