Registration Dossier
Registration Dossier
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EC number: 200-309-2 | CAS number: 57-06-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Allyl isothiocyanate
- EC Number:
- 200-309-2
- EC Name:
- Allyl isothiocyanate
- Cas Number:
- 57-06-7
- Molecular formula:
- C4H5NS
- IUPAC Name:
- 3-isothiocyanatoprop-1-ene
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA:J
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0, 2.5, 5, 10%
- No. of animals per dose:
- 5 per dose
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 6.09
- Test group / Remarks:
- 2.5%
- Parameter:
- SI
- Value:
- 10.31
- Test group / Remarks:
- 5%
- Parameter:
- SI
- Value:
- 9.11
- Test group / Remarks:
- 10%
- Parameter:
- EC3
- Remarks on result:
- not determinable
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- A dermal sensitization test was conducted with mice to determine the potential for IR9804 to produce sensitization after repeated topical application.
Based on the results of this study, the test substance is considered positive for dermal sensitization potential in the LLNA.
Since all dose levels induces a SI > 3.0, the EC3 could not be calculated.
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