Registration Dossier
Registration Dossier
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EC number: 200-309-2 | CAS number: 57-06-7
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Remarks:
- subcutaneous administration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- TOXICOLOGY OF GLUCOSINOLATES, RELATED COMPOUNDS (NITRILES, R-GOITRIN, ISOTHIOCYANATES) AND VITAMIN U FOUND IN CRUCIFERAE
- Author:
- K. NISHIE and M. E. DA.XENBICHLER
- Year:
- 1 980
- Bibliographic source:
- Fd Cosmer. To:dcol. Vol. 18. pp. 159 to 172
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two groups of pregnant Holtzman rats received 50 or 100 mg/kg bw allyl isothiocyanate by subcutaneous administration on days 8 and 9 of gestation.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Allyl isothiocyanate
- EC Number:
- 200-309-2
- EC Name:
- Allyl isothiocyanate
- Cas Number:
- 57-06-7
- Molecular formula:
- C4H5NS
- IUPAC Name:
- 3-isothiocyanatoprop-1-ene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Holtzman
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: Dissolved in either propylene glycol or distilled water
- Duration of treatment / exposure:
- 11-12 days after treatment.
- Frequency of treatment:
- One dose/day was administered on day 8 and/or 9 of gestation,
- Duration of test:
- 11-12 days after treatment.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 50 mg/kg bw/day (nominal)
- Dose / conc.:
- 100 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- 6 female rats/50 mg/kg bw
8 female rats/100 mg/kg bw - Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- 100 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: embryo death
Applicant's summary and conclusion
- Conclusions:
- Maternal toxicity was evident with the high dose. Foetuses were examined on day 20; those in the low-dose group weighted significantly less than controls, while an increased incidence of resorptions was seen in the high-dose group. No treatment-related malformation was observed.
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