Registration Dossier
Registration Dossier
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EC number: 200-309-2 | CAS number: 57-06-7
Long-term toxicity to fish
Administrative data
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- 28-days Larval Test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute and Long-Term Effects of Nine Chemicals on the Japanese Medaka (Oryzias latipes)
- Author:
- G.W.Holcombe, D.A.Benoit, D.E.Hammermeister, E.N.Leonard, R.D.Johnson
- Year:
- 1 995
- Bibliographic source:
- Arch. Environ. Contam. Toxicol. 28, 287-297 (1995)
Materials and methods
- Principles of method if other than guideline:
- 28-day larval survival and growth test was conducted with nine organic chemicals using the Japanese medaka (Oryzias latipes) as the test organism.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Allyl isothiocyanate
- EC Number:
- 200-309-2
- EC Name:
- Allyl isothiocyanate
- Cas Number:
- 57-06-7
- Molecular formula:
- C4H5NS
- IUPAC Name:
- 3-isothiocyanatoprop-1-ene
- Test material form:
- liquid
Constituent 1
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Oryzias latipes
Study design
- Test type:
- not specified
- Water media type:
- other: Lake Superior water
- Total exposure duration:
- 28 d
Test conditions
- Hardness:
- The mean and range for total hardness was 45.8 (38.0-52.0) mg/L as CaCO3 for all tests.
- Test temperature:
- 25 C +/- 1
- pH:
- 7.88 +/- 0.18
Results and discussion
Effect concentrations
- Key result
- Duration:
- 28 d
- Dose descriptor:
- other: Maximum Acceptable Toxicant Concentrations (MATs)
- Effect conc.:
- 0.013 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: survival or growth effect
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The estimated MATC for allyl isothiocyanate, based either on survival or growth effects, lies between 0.085 and 0.0185 mg/L. This MATC value yields a chronic value of 0.013 mg/L.
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