Registration Dossier
Registration Dossier
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EC number: 200-309-2 | CAS number: 57-06-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- yes
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Allyl isothiocyanate
- EC Number:
- 200-309-2
- EC Name:
- Allyl isothiocyanate
- Cas Number:
- 57-06-7
- Molecular formula:
- C4H5NS
- IUPAC Name:
- 3-isothiocyanatoprop-1-ene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- not specified
- Mass median aerodynamic diameter (MMAD):
- >= 1.67 - <= 3.21 µm
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0.05, 0.5 mg/L
- No. of animals per sex per dose:
- 10 (5 males and 5 female)
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.206 - < 0.508 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- An acute inhalation toxicity test was conducted with rats to determine the potential for IR9804 to produce toxicity from a single exposure via the inhalation (nose-only exposure) route. Under the conditions of this study, the 4-hour exposure acute inhalation LC50 of the test substance (calculated as a Time Weighted Average) appears to be between 0.206 and 0.508 mg/L in male and females rats.
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