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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.1200 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl isothiocyanate
EC Number:
200-309-2
EC Name:
Allyl isothiocyanate
Cas Number:
57-06-7
Molecular formula:
C4H5NS
IUPAC Name:
3-isothiocyanatoprop-1-ene
Test material form:
liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
The appropriate amount of test substance (200 or 2,000 mg/kg bw) was applied evenly over a dose area of approximately 10% of the body surface and covered with a gauze pad. After 24h of exposure to the substance, the pads were removed and the test sites were gently cleansed of any residual test substance.
Duration of exposure:
24h
Doses:
200 or 2,000 mg/kg bw
No. of animals per sex per dose:
10 (5 males and 5 females)
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 - < 2 000 mg/kg bw
Based on:
test mat.
Mortality:
200 mg/kg bw: 0/10
2,000 mg/kg bw: 9/10

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
An acute dermal toxicity test was conducted with rats to determine the potential for IR9804 to produce toxicity from a single topical application. Under test conditions of this study, the single dose acute dermal LD50 of the test substance is between 200 and 2,000 mg/kg bw of body weight in male and female rats.