Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-509-8 | CAS number: 107-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Fish
In a static test system a 96h-LC0 of ≥ 100 mg/L was determined on Brachydanio rerio (new name: Danio rerio) related to nominal concentration. As a consequence it can be concluded the 96h-LC50 is > 100 mg/L. The test was conducted according to EU Method C.1 (Acute Toxicity for Fish).
Daphnia
Daphnia magna was investigated in a semi-static test according to the OECD Guideline 202. No toxic effect was observed and a 48h-LC50 of >100 mg/L was received. The LC50-value relates to nominal concentration as the analytically determined values vary not more than 6.2 %.
Alga
According to OECD guideline 201 ' Alga, Growth Inhibition Test' the acute toxicity of dibutyl hydrogen phosphate to alga (Desmodesmus subspicatus) was tested. After 72 hours an ErC50 of >100 mg/L and ErC10 of 76 mg/L was received and a NOEC of 50 mg/L was calculated.
The lowest concentration 3.1 mg/L slightly dropped below the 80% recovery limit during the 72-hour exposure period. This is considered as not significant, because the highest determined concentration remained stable over the exposure time and therefore all results are expressed in terms of nominal concentrations.
Microorganisms
To assess the toxicity of dibutyl hydrogen phosphate to microorganisms a study was conducted according to the OECD Guideline 209. Dibutyl hydrogen phosphate showed no respiration inhibition of activated sludge at a concentration of 10000 mg/L. The EC50 is higher than 10000 mg/L.
The effect value related to nominal concentration, since no analytical monitoring was performed.
Additional information
A testing proposal according to REACH Annex IX 9.1.5. ‘Long-term toxicity testing on invertebrates, (unless already provided as part of Annex VIII requirements)’ is included as a standard information requirement. The OECD TG 211 Daphnia magna Reproduction Test is regarded to be the most suitable test for addressing the information requirements.
Additionally, a conditional testing proposal according to REACH Annex IX, 9.1.6. ‘Long-term toxicity testing on fish, (unless already provided as part of Annex VIII requirements)’ is included in the dossier as a standard information requirement and cannot be generated otherwise. The Fish Early Life Stage (FELS) toxicity test (OECD TG 210) is regarded as the most suitable test guideline for addressing the information requirements is included in the dossier based on BoA decisions A-010-2018 and A-011-2018. As the BoA decision A-010-2018 is currently being challenged before the General Court (T-656/20), we respectfully request ECHA to suspend any decision on the testing proposal and to first await the decision of the General Court in the aforementioned case. Vertebrate studies should always be the last resort to generate information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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