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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Organophosphate esters and their metabolites in paired human whole blood, serum, and urine as biomarkers of exposure
Author:
Hou M
Bibliographic source:
Environment International 139 (2020) 105698

Materials and methods

Type of study / information:
dibutyl phosphate concentration in human whole blood, serum and urine as biomarkers of exposure

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl hydrogen phosphate
EC Number:
203-509-8
EC Name:
Dibutyl hydrogen phosphate
Cas Number:
107-66-4
Molecular formula:
C8H19O4P
IUPAC Name:
dibutyl hydrogen phosphate

Results and discussion

Any other information on results incl. tables

In this study, we detected sixteen OPEs and ten di-OPEs in 52 paired whole blood, serum, and urine samples collected in Beijing, China to investigate the correlations between different compounds and matrices, thus providing proper biomarkers of human exposure to OPEs. The order of the median concentrations of ΣOPEs was whole blood (8.63 ng/mL) > serum (5.71 ng/mL) > urine (0.396 ng/mL), while those of Σdi-OPEs followed the order of urine (16.6 ng/mL) > whole blood (5.97 ng/mL) > serum (3.70 ng/mL). Ethylhexyl diphenyl phosphate (EHDPP) and cresyl diphenyl phosphate (CDPP) were the dominant OPEs in both whole blood and serum samples and were significantly correlated between these two matrices. The distribution of OPEs in human blood was evaluated according to serum-to whole blood concentration ratios (S:WB ratios). The median S:WB ratios of triethyl phosphate (TEP), tri-n-butyl phosphate (TnBP), bisphenol-A bis(diphenyl phosphate) (BABP), EHDPP, and CDPP were lower than 1, indicating that these OPEs preferred to accumulated in blood cells rather than in serum/plasma. Tributyl phosphate and dibutyl phosphate were found in/or whole blood, serum and urine samples with geometric means of about 0.2 ng/mL. The calculation of serum-to whole-blood concentration ratios suggested that TnBP was predominantly accumulated in the blood-cell fraction.

Applicant's summary and conclusion