Registration Dossier
Registration Dossier
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EC number: 203-509-8 | CAS number: 107-66-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- Estimated by calculation.
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Estimated by calculation.
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Dibutylphosphat und seine technischen Gemische - The MAK collection of occupational Health and safety, 47. Lieferung, 2009
- Author:
- anonymous
- Year:
- 2 009
- Bibliographic source:
- DFG Deutsche Forschungsgemeinschaft, Wiley-VCH Verlag GmbH, D-69451 Weinheim, Germany
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Calculation of the dermal penetration of dibutyl hydrogen phosphate by mathematical models.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dibutyl hydrogen phosphate
- EC Number:
- 203-509-8
- EC Name:
- Dibutyl hydrogen phosphate
- Cas Number:
- 107-66-4
- Molecular formula:
- C8H19O4P
- IUPAC Name:
- dibutyl hydrogen phosphate
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: not applicable - calculation by a mathematical model
- Strain:
- other: not applicable - calculation by a mathematical model
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- other: not applicable - calculation by a mathematical model
- Vehicle:
- other: not applicable - calculation by a mathematical model
- Duration of exposure:
- not applicable - calculation by a mathematical model
- Doses:
- not applicable - calculation by a mathematical model
- No. of animals per group:
- not applicable - calculation by a mathematical model
- Control animals:
- no
Results and discussion
- Total recovery:
- Mathematical model calculations of skin permeation of dibutyl hydrogen phosphate revealed a for a one-hour exposition of hands and forearms an adsorption rate of 10.7 to 14.4 mg (ca. 0.2 mg/kg bw/day).
- Conversion factor human vs. animal skin:
- not applicable - calculation by a mathematical model
Any other information on results incl. tables
Mathematical model calculations of skin permeation of dibutyl hydrogen phosphate revealed a for a one-hour exposition of hands and forearms an adsorption rate of 10.7 to 14.4 mg (ca. 0.2 mg/kg bw/day).
Applicant's summary and conclusion
- Executive summary:
Mathematical model calculations of skin permeation of dibutyl hydrogen phosphate revealed a for a one-hour exposition of hands and forearms an adsorption rate of 10.7 to 14.4 mg (ca. 0.2 mg/kg bw/day).
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