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Registration Dossier
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EC number: 203-509-8 | CAS number: 107-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and well documented
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of tributyl phosphate in male rats
- Author:
- Suzuki T, Sasaki K, Takeda M, Uchiyama M
- Year:
- 1 984
- Bibliographic source:
- J Agric Food Chem 32, 603-610 (1984)
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- The urinary metabolites of dibutyl hydrogen phosphate were examined in rats after a single intraperitoneal application 1-3 days after dose.
Test material
- Reference substance name:
- Dibutyl hydrogen phosphate
- EC Number:
- 203-509-8
- EC Name:
- Dibutyl hydrogen phosphate
- Cas Number:
- 107-66-4
- Molecular formula:
- C8H19O4P
- IUPAC Name:
- dibutyl hydrogen phosphate
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Remarks:
- 10 % solution
- Duration and frequency of treatment / exposure:
- single injection
Doses / concentrations
- Remarks:
- Doses / Concentrations:
250 mg/kg bw
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
- Preliminary studies:
- no data
Main ADME results
- Type:
- metabolism
- Results:
- When rats were dosed with dibutyl hydrogen phosphate, much of it (47.6 %) was recovered intact in the urine.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data
- Details on distribution in tissues:
- no data
- Details on excretion:
- no data
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- no data
Any other information on results incl. tables
When rats were dosed with dibutyl hydrogen phosphate, much of it (47.6%) was recovered intact, and only small amounts of the carboxylated (0.1%) or hydroxylated (0.08%) (in the butyl side chain) derivates were formed, as well as some butyl dihydrogen phosphate (0.03%) was found.
After a single intraperitoneal dose of tributyl phosphate at 250 mg/kg bw, the major metabolite were dibutyl hydrogen phosphate, butyl dihydrogen phosphate and butyl bis(3-hydroxybutyl) phosphate.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: low bioaccumulation potential based on study results
- Executive summary:
Male Wistar rats (180 -210 g) were given a single intraperitoneal (ip) injection of dibutyl hydrogen phosphate dissolved 10% in corn oil at a dosage of 250 mg/kg bw. Urinary metabolites were investigated on day 1-3 after application.
When rats were dosed with dibutyl hydrogen phosphate, the majority (47.6 %) was recovered intact, and only small amounts of the carboxylated (0.1 %) or hydroxylated (0.08) (in the butyl side chain) derivates were formed, as well as some butyl dihydrogen phosphate (0.03 %) was found.
After a single intraperitoneal dose of tributyl phosphate at 250 mg/kg bw, the major metabolite were dibutyl hydrogen phosphate, butyl dihydrogen phosphate and butyl bis(3-hydroxybutyl) phosphate.
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