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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and sufficient documented

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
5 male and 5 female rats were administered a single dose of dibutyl hydrogen phosphate per gavage. Animals were observed for mortality, body weight and clinical signs. A gross necropsy was performed on animals sacrificed at the end of the study.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl hydrogen phosphate
EC Number:
203-509-8
EC Name:
Dibutyl hydrogen phosphate
Cas Number:
107-66-4
Molecular formula:
C8H19O4P
IUPAC Name:
dibutyl hydrogen phosphate

Test animals

Species:
rat
Strain:
other: Crj:CD(SD)
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5 males and 5 females/dose
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: No deaths occurred
Mortality:
none
Clinical signs:
other: During the course of the study, a decrease in locomotor activity, deep and slow respiration, blepharoptosis and blotted fur with urine on the lower abdomen were observed in males and females, and lacrimation and red urine were additionally observed in som
Gross pathology:
No macroscopic abnormalities were seen in pathological examination for both male and female groups.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 > 2000 mg/kg bw (rats, male and female).
Executive summary:

Five male and five female rats were administered a single dose of dibutyl hydrogen phosphate per gavage. Animals were observed for mortality, body weight and clinical signs. A gross necropsy was performed on animals sacrificed at the end of the study.


During the course of the study, a decrease in locomotor activity, deep and slow respiration, blepharotosis and blotted fur with urine on the lower abdomen were observed in males and females, and lacrimation and red urine were additionally observed in some rats.


Body weight gain was slightly suppressed on the following day of treatment in many rats. No deaths occurred, and no macroscopic abnormalities were seen in pathological examination for both male and female groups.


LD50 > 2000 mg/kg bw (rats, male and female)