Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-171-4 | CAS number: 117-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- A rat teratology study with Tetrathal (tetrachlorophthalic anhydride)
- Author:
- Nair RS, Johannsen FR, Levinskas GJ, Schroeder RE
- Year:
- 1 984
- Bibliographic source:
- Federation Proceedings 43, 365
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Principles of method if other than guideline:
- Pregnant Sprague-Dawley rats (24 mated females/dose) were administered Tetrachlorophthalic anhydride (CASRN 117-08-8) in corn oil via gavage at 0, 250, 1000 or 2000 mg/kg-bw/day during gestation days 6 – 19.
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrachlorophthalic anhydride
- EC Number:
- 204-171-4
- EC Name:
- Tetrachlorophthalic anhydride
- Cas Number:
- 117-08-8
- Molecular formula:
- C8Cl4O3
- IUPAC Name:
- tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 14 days (gestation day 6 to 19)
- Frequency of treatment:
- once daily
- Duration of test:
- animals were killed on day 20
- No. of animals per sex per dose:
- 24 females/dose
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 2 000 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects. Remark: at 1000 mg/kg bw
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
No treatment-related parental mortality was observed. Lethargy was observed in several adult females soon after dosing at 2000 mg/kgbw/day, as early as gestation day 6. Pale eye color was observed in four adults at 2000 mg/kgbw/day on gestation day 20. Developmental effects were observed at 2000 mg/kg-bw/day and included reduced fetal body weight, a slight increase in the incidence of asymmetric/unossified sternebra and incompletely ossified thoracic vertebral centra and an increase in the incidence of rib and vertebral malformations.
Applicant's summary and conclusion
- Executive summary:
Pregnant Sprague-Dawley rats (24 mated females/dose) were administered CASRN 117-08-8 in corn oil via gavage at 0, 250, 1000 or 2000 mg/kg-bw/day during gestation days 6 – 19. Animals were observed twice daily for mortality and abnormal behavior. Clinical observations and body weight were recorded at several intervals throughout the study. On gestation day 20, animals were sacrificed and uterine horns were examined for implantation sites, resorptions and the number of viable or non-viable fetuses. The number of corpora lutea was also recorded. The sex and weights of all live fetuses were recorded and all fetuses were examined for external abnormalities. One half of the fetuses were examined for skeletal malformations and the other half were examined for internal anomalies. No treatment-related parental mortality was observed. Lethargy was observed in several adult females soon after dosing at 2000 mg/kgbw/day, as early as gestation day 6. Pale eye color was observed in four adults at 2000 mg/kgbw/day on gestation day 20. Developmental effects were observed at 2000 mg/kg-bw/day and included reduced fetal body weight, a slight increase in the incidence of asymmetric/unossified sternebra and incompletely ossified thoracic vertebral centra and an increase in the incidence of
rib and vertebral malformations.
NOAEL (maternal toxicity) = 2000 mg/kg-bw/day (highest dose tested)
LOAEL (developmental toxicity) = 2000 mg/kg-bw/day (based on skeletal malformations and
reduced fetal weight)
NOAEL (developmental toxicity) = 1000 mg/kg-bw/day
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.