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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The acute toxicity to fish (Oryzias latipes) was measured during 96 hours and showed a LC50 >106 mg/L. The substance does not to be classified based on the result of this study in accordance with the criteria set in Directive 67/548/EC and Regulation (EC) 1272/2008 including the Regulation (EC) 286/2011.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
106 mg/L

Additional information

No assignable toxicity tests to fish using tetrachlorophthalic anhydride as test substance are available.

As tetrachlorophthalic anhydride hydrolysis rapidly in water forming the the hydrolysis product tetrachlorophthalic acid (CAS , tests with tetrachlorophthalic acid are used to draw a conculsionon toxicity to fish.

At the National Institute of Technology and Evaluation, Japan, acute toxicity to fish (Oryzias latipes) with tetrachlorophthalic acid as test substance was determined according to the OECD TG 203. Tetrachlorophthalic acid was exposed to a test solution of a nominal test substance concentration of 100 mg/L and to a blank control solution for a period of 96 h under semi static conditions in buffered medium. Mobility and visible abnormalities were recorded at 24, 48, 72 and 96 h. The mesured concentrations confirmed that deviation from the nominal concenntrations was less than 20 % (measured concentrations were range of 80 - 102.2 % of nominal concentrations). No toxic effect and abnormal behavior were observed. This toxicity study is classified as acceptable and satisfies the guideline requirements for the acute fish study.