Registration Dossier
Registration Dossier
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EC number: 204-171-4 | CAS number: 117-08-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
Materials and methods
- Principles of method if other than guideline:
- Tetraphthalic anhydride was applied to the closely shaved intact skin of New Zealand albino male and female rabbits and held in place for 24 hours to define a Minimum Lethal Dose. The animals were observed for mortaliy, weight change and clinical signs.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Tetrachlorophthalic anhydride
- EC Number:
- 204-171-4
- EC Name:
- Tetrachlorophthalic anhydride
- Cas Number:
- 117-08-8
- Molecular formula:
- C8Cl4O3
- IUPAC Name:
- tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Duration of exposure:
- 24 hours
- Doses:
- Doses in mg/kg bw; F = female rabbits, M = male rabbits
501 (1F), 794 (1M), 1260 (1F), 2000 (1M), 3160 (1F) or 5010 (1M) - No. of animals per sex per dose:
- Doses in mg/kg bw; F = female rabbits, M = male rabbits
501 (1F), 794 (1M), 1260 (1F), 2000 (1M), 3160 (1F) or 5010 (1M) - Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 5 010 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No deaths occurred in the study at any dose level; The only manifestation of toxicity was generalized reduced activity.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information
- Executive summary:
Groups of single rabbits were treated dermally with either 501 (1F), 794 (1M), 1260 (1F), 2000 (1M), 3160 (1F) or 5010 (1M) mg/kg test article ( ground powder in a 10% corn oil suspension) to define a Minimum Lethal Dose. All animals had their dorsal region closely shaved and test material applied to intact skin under an occlusive patch and held in place for 24 hours. Thereafter, the test article was wiped off. All animals were observed daily for signs of toxicity and weighed prior to and at study term (5 days).
No deaths occurred in the study at any dose level; The only manifestation of toxicity was generalized reduced activity.
LC0 > 5010 mg/kg bw (rabbit, male and female)
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