Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-171-4 | CAS number: 117-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Tetrachlorophthalic anhydride reacts rapidly with water, forming tetrachlorophthalic acid (CAS 632-58-6). Tests with tetrachlorophthalic anhydride in aquatic solutions measure effects of tetrachlorophthalic acid rather than effects of tetrachlorophthalic anhydride. Consequently, tetrachlorophthalic acid can also be used to evaluate the aquatic effects of tetrachlorophthalic anhydride.
Tetrachlorophthalic acid is a weak to medium strong acid and partly dissociating in water causing a pH shift (pKa1: 3.01; pKa2: 0.55). The tolerance of water organisms towards pH is diverse. Recommended pH values for test species listed in OECD guidelines are between 6 and 9.
Toxicity to fish:
Acute toxicity to fish (Oryzias latipes) was determined according to the OECD TG 203 at the National Institute of Technology and Evaluation, Japan . Tetrachlorophthalic acid was used as test substance and the test was carried out in buffered medium. No toxic effect and abnormal behavior were observed. Analytical monitoring was carried out in this test showing stability of the test substance during 96 hours of exposure. A LC 50 of > 106 mg/l, based on measured concentration was obtained.
Toxicity to daphnia:
Concerning the toxicity towards aquatic invertebrates, an acute toxicity test to Daphnia magna with the hydrolysis product tetrachlorophthalic acid is taken into account to draw a conclusion on toxicity towards aquatic invertebrates for tetrachlorophthalic anhydride. The study was performed according to the OECD TG 202 at the National Institute of Technology and Evaluation, Japan. No toxic effect and abnormal behavior were observed during 48 hours of exposure in buffered medium. As analytical monitoring was performed showing stability of the test substance, the result of EC 50 > 104 mg/l relates to measured concentrations.
Toxicity to algae:
In a test, the fresh water alga Pseudokirchenerilla subcapitata was exposed to the hydrolysis product tetrachlorophthalic acid for 72 hours. The experiment was conducted according to the OECD TG 201 at the National Institute of Technology and Evaluation, Japan. An EC50 of 84 mg/l and a NOEC of 25 mg/l, based on measured concentrations was obtained in this test. Analytical monitoring was carried out and stability of the test substance was confimed during the duration of exposure. Although, at the highest test concentration the pH decreases below the tolerance limit of algae, and the effect observed may be mainly caused due to the pH shift of the substance, the result of this study is regarded as reliable and is used for assessment.
Toxicity to microorganisms:
The effect of tetrachlorophthalic anhydride on aerobic biological sewage treatment processes was assessed according to Official Journal of the EG L 133 Part C: Biodegradability, by determining inhibition of respiration of the mixed community of microorganisms present in a sample of activated sludge. Activated sludge obtained from a laboratory unit fed with predominantly domestic sewage was exposed for a period of three hours. No respiration inhibition, relative to the mean control rate, occurred in any of the tetrachlorophthalic anhydride treatments and the 3-h EC50 was therefore >10000 mg tetrachlorophthalic anhydride/L, the highest concentration tested.
All studies are classified as acceptable and satisfy the guideline requirements for the toxicity studies to aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.