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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

A valid Ames test and a chromosome aberration test (CA) in combination with a sister chromatid exchange test (SCE) are available for tetrachlorophthalic anhydride.
Additional a valid HPRT test with phthalic anhydride (as a surrogate for tetrachlorophthatlic anhydride) is available.

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

The Ames test and the combined CA and SCE test were negative.

Justification for classification or non-classification

Due to the negative results of the available assays tetrachlorophthalic anhydride is regarded as non-mutagenic. A classification is therefore not justified.