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Ecotoxicological information

Toxicity to terrestrial arthropods

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Endpoint:
toxicity to terrestrial arthropods: short-term
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991-05-23 - 1991 -09-01
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
according to guideline
Guideline:
other: BBA 23-2.1.8 (1990)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Application method:
spray
Analytical monitoring:
no
Vehicle:
yes
Remarks:
water
Test organisms (species):
Poecilus cupreus
Animal group:
Coleoptera (soil-dwelling carabid beetle)
Details on test organisms:
3 male and 3 female animals
Study type:
laboratory study
Limit test:
no
Total exposure duration:
14 d
Post exposure observation period:
no
Test temperature:
17 - 25 °C
Photoperiod and lighting:
16 h/day
Nominal and measured concentrations:
Nominal:
1.944 kg/ha
Reference substance (positive control):
no
Key result
Duration:
14 d
Dose descriptor:
NOEC
Effect conc.:
1 944 g/ha
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
yes
Conclusions:
NOEC: 1.944 kg/ha soil.
Executive summary:

In a 14 day acute contact toxicity study, ground beetles (Poecilus cupreus-Imagines) were exposed to 3-Methylpyrazol administered by contact with soil at an application rate of 1,944 kg/ha soil in accordance with the guideline BBA 23-2.1.8 (1990). Neither mortality nor reduced food consumption were observed.

Endpoint:
toxicity to terrestrial arthropods: short-term
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991-03-15 - 1991-09-01
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Deviation from guideline: direct feeeding of single honeybees without anesthetization.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 213 (Honeybees, Acute Oral Toxicity Test)
Deviations:
yes
Remarks:
no anesthetization of the honeybees
GLP compliance:
yes (incl. QA statement)
Application method:
oral
Analytical monitoring:
no
Vehicle:
yes
Test organisms (species):
Apis mellifera
Animal group:
Hymenoptera (honeybees)
Study type:
laboratory study
Limit test:
no
Total exposure duration:
24 h
Reference substance (positive control):
yes
Remarks:
Parathionmethyl 575 g/L
Key result
Duration:
24 h
Dose descriptor:
LD50
Effect conc.:
>= 50 - <= 100 µg per animal
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
yes
Conclusions:
The acute oral LD50 of 3-Methylpyrazol to honeybees is 500-1000 mg/kg bw.
Executive summary:

In a 24 hr-acute oral toxicity study, honey bees (Apis mellifera L.) were exposed to 3-Methylpyrazol administered in the feed solution (0.1 ml of 1% solution of 3-Methylpyrazol in water) similar to OECD 213. The LD50 value was 50 - 100 µg a.i./bee. 

Wight of one honey bee: approx. 100 mg according to Spürgin: DIe Honigbiene, Ulmer Verlag, 2008

Based on this body weight the LD50 can be estimated with 50 microg per 100 mg bodyweight - 500 mg per kg bodyweight

Description of key information

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil dwelling arthropods:
1 944 000 mg/kg soil dw

Additional information