Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-925-7 | CAS number: 1453-58-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibitory effect of 3-Methylpyrazole of the respiration of activated sludge was determined as: 3h NOEC = 320 mg/l
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 320 mg/L
Additional information
Two GLP-studies with Klimisch score 1 are available:
The inhibitory effect of 3-Methylpyrazol on bacteria multiplication was tested by the Pseudomonas cell multiplication inhibition test according DIN 38 412, part 8.
The values of the effective concentrations are: EC10 124 mg/1, EC50 449 mg/1. The Inhibition of the Respiration of Activated Sludge when exposed to 3-Methylpyrazol was determined according to OECD 209 resp. EU C.11.The following results for the test item 3-Methylpyrazol were determined:
inhibition based on total respiration:
3h NOEC < 1 mg/l
3h EC20 > 1000 mg/l
3h EC50 approx. 1000 mg/l
Inhibition based on heterotrophic respiration:
3h NOEC = 320 mg/L
3h EC20 > 1000 mg/L
3h EC50 > 1000 mg/L
The lowest NOEC value is chosen as key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
