Registration Dossier
Registration Dossier
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EC number: 215-925-7 | CAS number: 1453-58-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibitory effect of 3-Methylpyrazole of the respiration of activated sludge was determined as: 3h NOEC = 320 mg/l
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 320 mg/L
Additional information
Two GLP-studies with Klimisch score 1 are available:
The inhibitory effect of 3-Methylpyrazol on bacteria multiplication was tested by the Pseudomonas cell multiplication inhibition test according DIN 38 412, part 8.
The values of the effective concentrations are: EC10 124 mg/1, EC50 449 mg/1. The Inhibition of the Respiration of Activated Sludge when exposed to 3-Methylpyrazol was determined according to OECD 209 resp. EU C.11.The following results for the test item 3-Methylpyrazol were determined:
inhibition based on total respiration:
3h NOEC < 1 mg/l
3h EC20 > 1000 mg/l
3h EC50 approx. 1000 mg/l
Inhibition based on heterotrophic respiration:
3h NOEC = 320 mg/L
3h EC20 > 1000 mg/L
3h EC50 > 1000 mg/L
The lowest NOEC value is chosen as key study.
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