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EC number: 215-925-7 | CAS number: 1453-58-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-06-25 - 2008-10-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.475
- Temp.:
- 25 °C
- pH:
- 6.9
- Conclusions:
- The procedure was performed according to Method A.8, Partition coefficient, Council Regulation (EC) No 440/2008, Published in O.J. L 142, 2008.
In accordance with the estimated values of log Pow (0.78 ± 0.22), it was decided to use the HPLC method for partition coefficient determination.
The partition coefficient of the test substance 3-Methylpyrazol is :
log P = 0.475 ± 0.398 (25 °C, pH = 6.9) - Executive summary:
The procedure was performed according to Method A.8, Partition coefficient, Council Regulation (EC) No 440/2008, Published in O.J. L 142, 2008. In accordance with the calculated values of log Pow (0.78 ± 0.22), it was decided to use the HPLC method for partition coefficient determination. The partition coefficient of the test substance 3-Methylpyrazol is : log P = 0.475 ± 0.398 (25 °C, pH = 6.9)
Reference
Description of key information
The partition coefficient of the test substance 3-Methylpyrazol is : log P = 0.475 ± 0.398 (25 °C, pH = 6.9)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.475
- at the temperature of:
- 25 °C
Additional information
The reported study is GLP compliant and has Klimisch score 1. The partition coefficient of the test substance 3-Methylpyrazol is : log P = 0.475 ± 0.398 (25 °C, pH = 6.9)
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