Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-06-25 - 2008-10-21
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.475
Temp.:
25 °C
pH:
6.9
Conclusions:
The procedure was performed according to Method A.8, Partition coefficient, Council Regulation (EC) No 440/2008, Published in O.J. L 142, 2008.

In accordance with the estimated values of log Pow (0.78 ± 0.22), it was decided to use the HPLC method for partition coefficient determination.

The partition coefficient of the test substance 3-Methylpyrazol is :

log P = 0.475 ± 0.398 (25 °C, pH = 6.9)
Executive summary:

The procedure was performed according to Method A.8, Partition coefficient, Council Regulation (EC) No 440/2008, Published in O.J. L 142, 2008. In accordance with the calculated values of log Pow (0.78 ± 0.22), it was decided to use the HPLC method for partition coefficient determination. The partition coefficient of the test substance 3-Methylpyrazol is : log P = 0.475 ± 0.398 (25 °C, pH = 6.9)

Description of key information

The partition coefficient of the test substance 3-Methylpyrazol is : log P = 0.475 ± 0.398 (25 °C, pH = 6.9)

Key value for chemical safety assessment

Log Kow (Log Pow):
0.475
at the temperature of:
25 °C

Additional information

The reported study is GLP compliant and has Klimisch score 1. The partition coefficient of the test substance 3-Methylpyrazol is : log P = 0.475 ± 0.398 (25 °C, pH = 6.9)