Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
other: publication
Adequacy of study:
supporting study
Study period:
1990
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: no guideline followed

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
no guideline followed
Guideline:
other: not applicable
Deviations:
not specified
GLP compliance:
not specified
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methylpyrazole
EC Number:
215-925-7
EC Name:
3-methylpyrazole
Cas Number:
1453-58-3
Molecular formula:
C4H6N2
IUPAC Name:
3-methyl-1H-pyrazole
Test material form:
other: liquid

Test animals

Species:
rat
Sex:
female

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Basis for effect level:
other: no NOAEL identified
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Observed effects

At doses of 20, 40, 80 and 180 mg/kg bw no maternal toxicity was observed. At 80 mg/kg bw urogenital syndrom (uni- and bilateral renal agenesis, hydronephrosis, incomlete formation of uterus) occured. No embryotoxicity was noted.
At 160 mg/kg postnatal viability and live-birth indices were decreased.

Applicant's summary and conclusion

Conclusions:
At doses of 20, 40, 80 and 180 mg/kg bw no maternal toxicity was observed. At 80 mg/kg bw urogenital syndrom (uni- and bilateral renal agenesis, hydronephrosis, incomlete formation of uterus) occured. No embryotoxicity was noted.
At 160 mg/kg postnatal viability and live-birth indices were decreased.