Registration Dossier
Registration Dossier
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EC number: 215-925-7 | CAS number: 1453-58-3
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- other: publication
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: no guideline followed
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: not applicable
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 3-methylpyrazole
- EC Number:
- 215-925-7
- EC Name:
- 3-methylpyrazole
- Cas Number:
- 1453-58-3
- Molecular formula:
- C4H6N2
- IUPAC Name:
- 3-methyl-1H-pyrazole
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Sex:
- female
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Basis for effect level:
- other: no NOAEL identified
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Observed effects
At 160 mg/kg postnatal viability and live-birth indices were decreased.
Applicant's summary and conclusion
- Conclusions:
- At doses of 20, 40, 80 and 180 mg/kg bw no maternal toxicity was observed. At 80 mg/kg bw urogenital syndrom (uni- and bilateral renal agenesis, hydronephrosis, incomlete formation of uterus) occured. No embryotoxicity was noted.
At 160 mg/kg postnatal viability and live-birth indices were decreased.
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