Registration Dossier
Registration Dossier
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EC number: 215-925-7 | CAS number: 1453-58-3
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-08-11 - 2008-11-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 25 oC
- Details on study design: HPLC method:
- Column: ZORBAX CN, 5|im, 150 x 4.6 mm
Mobile phase: 550 mL of 0.01 M citrate-buffer pH = 6.0 + 450 ml of methanol
Detection:
210 nm - NaN03
240 nm - the reference substances
214 nm - the test substance
Flow: 1.0 mL/ min
Injection volume: 10 µL
Column temp.: 25°C - Analytical monitoring:
- yes
- Key result
- Type:
- log Koc
- Value:
- 1.2
- Temp.:
- 25 °C
- Remarks on result:
- other: Soil
- Key result
- Type:
- log Koc
- Value:
- 1.2
- Temp.:
- 25 °C
- Remarks on result:
- other: Sewage sludge
- Details on results (HPLC method):
- Compound Retention time tK (min)
I II III IV
Test substance 2.337 2.337 2.337 2.338 - Transformation products:
- not measured
- Validity criteria fulfilled:
- yes
- Conclusions:
- Adsorption coefficient of 3-Methylpyrazol on soil:
log Koc (soil) = 1.2 +/- 0.8 (pH = 6.0; 25°C)
Adsorption coefficient of 3-Methylpyrazol on sewage sludge:
log Koc (sludge) = 1.2 +/- 0.8 (pH = 6.0; 25°C)
The log Koc values lie outside the limits of applicability of used method. Because the determined adsorption coefficients are close to the lower limit of the method, the result may be considered reliable. - Executive summary:
The adsorption coefficient of test substance, 3-Methylpyrazol, on soil and on sewage sludge was estimated. The HPLC method with reference compounds was used. The test was performed according to the Method C.19, Estimation of the adsorption coefficient (Koe) on soil and sewage sludge using high performance liquid chromatography (HPLC), Council Regulation (EC) No 440/2008, Published in O.J.I. 142, 2008.
Adsorption coefficient of 3-Methylpyrazol on soil: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)
Adsorption coefficient of 3-Methylpyrazol on sewage sludge: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)
Reference
The retention times of the reference compounds
Reference compound |
Retention timetn(min) |
|||
I |
II |
III |
IV |
|
Acetanilide |
2.726 |
2.725 |
2.725 |
2.725 |
Benzamide |
2.375 |
2.374 |
2.375 |
2.375 |
2-Nitrobenzamide |
2.281 |
2.283 |
2.283 |
2.282 |
Atrazin |
3.809 |
3.808 |
3.808 |
3.808 |
Aniline |
2.591 |
2.593 |
2.592 |
2.591 |
2.5-Dichloroaniline |
4.666 |
4.666 |
4.665 |
4.664 |
Phenyl benzoate |
8.145 |
8.145 |
8.142 |
8.138 |
Retention times of the test substance
Compound |
Retention timetn(min) |
|||
I |
II |
III |
IV |
|
Test substance |
2.337 |
2.337 |
2.337 |
2.338 |
Description of key information
Adsorption coefficient of 3-Methylpyrazol on soil: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)
Adsorption coefficient of 3-Methylpyrazol on sewage sludge: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)
solids/water coefficient was calculated with EUSES 2.1 = 0.95 m3 x m-3 => log kp solids/water = 0 L/kg for a density of 1
suspended-matter/water coefficient was calculated with EUSES 2.1 = 1.36 m3 x m-3 => log kp suspended-matter/water = 0.13 L/kg for a density of 1
sediment-matter/water coefficient was calculated with EUSES 2.1 = 1.26 m3 x m-3 => log kp suspended-matter/water = 0.1 L/kg for a density of 1
Key value for chemical safety assessment
- Koc at 20 °C:
- 15.8
Other adsorption coefficients
- Type:
- log Kp (sediment-water)
- Value in L/kg:
- 0.1
- at the temperature of:
- 25 °C
Other adsorption coefficients
- Type:
- log Kp (suspended matter-water)
- Value in L/kg:
- 0.13
- at the temperature of:
- 25 °C
Additional information
The reported study is GLP compliant and has Klimisch score 1.
Adsorption coefficient of 3-Methylpyrazol on soil: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)
Adsorption coefficient of 3-Methylpyrazol on sewage sludge: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)
[LogKoc: 1.2]
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