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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
6/81 - 12/82
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No analysis of possible metabolites was performed.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Objective of study:
absorption
distribution
excretion
metabolism
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methylpyrazole
EC Number:
215-925-7
EC Name:
3-methylpyrazole
Cas Number:
1453-58-3
Molecular formula:
C4H6N2
IUPAC Name:
3-methyl-1H-pyrazole
Test material form:
other: liquid
Details on test material:
14C-radiolabelling
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Duration and frequency of treatment / exposure:
single exposure: absorption, distribution, excretion, passage of placental barrier
five time exposure: accumulation
seven time exposure: metabolism
Doses / concentrations
Remarks:
Doses / Concentrations:
single and five time exposure: 5 mg/kg body weight
seven time exposure: 50 mg/kg body weight
No. of animals per sex per dose / concentration:
absorption, distribution, excretion: 5 males and 5 females
metabolism: 3 males and 3 females
passage of placental barrier: 3 animals
Control animals:
no

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
blood concentration 0.001 % of administered dose after 240 min
Type:
excretion
Results:
93-96% after 24 hours

Toxicokinetic / pharmacokinetic studies

Transfer into organs
Key result
Test no.:
#1
Transfer type:
blood/placenta barrier
Toxicokinetic parameters
Key result
Test no.:
#1
Toxicokinetic parameters:
half-life 1st: 1-24 hours

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
After oral administration of 3-Methylpyrazol to male and female rats the maximal organ burden was determined after 30-60 minutes. Thereafter the substance is quickly eliminated (93-96% after 24 hours) via urine. A slightly increased 14C-activity was observed in all organs.
3-Methylpyrazol crosses the placental barrier.
Executive summary:

After oral administration of 3-Methylpyrazol to male and female rats the maximal organ burden was determined after 30-60 minutes. Thereafter the substance is quickly eliminated (93-96% after 24 hours) via urine. A slightly increased 14C-activity was observed in all organs. 3-Methylpyrazol crosses the placental barrier.