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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexylamine
EC Number:
203-629-0
EC Name:
Cyclohexylamine
Cas Number:
108-91-8
Molecular formula:
C6H13N
IUPAC Name:
cyclohexanamine
Details on test material:
IUCLID4 Test substance: other TS: as prescribed by chapter 1 BASF AG

Test animals

Species:
rabbit
Details on test animals or test system and environmental conditions:
Dermal application of undiluted test substance to the back of rabbitsfor up to 20 hours and a post exposure observation time of up to 8 days

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
no data
Duration of treatment / exposure:
up to 20 hours
Observation period:
up to 8 days
Number of animals:
no data
Details on study design:
Dermal application of undiluted test substance to the back of rabbitsfor up to 20 hours and a post exposure observation time of 8 days

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: finding after 1 min exposure
Basis:
mean
Time point:
other: 24 hours, 8 days
Reversibility:
other: necrosis, not reverible
Remarks on result:
other: scores were not given
Irritation parameter:
other: finding after 5 min and 15 nin of exposure
Basis:
mean
Time point:
other: 24 hours and 8 days
Reversibility:
other: marked necrosis, not reversible
Remarks on result:
other: scores were not given
Irritation parameter:
other: finding after 20 hours of exposure
Basis:
mean
Time point:
other: 24 hours and 8 days
Reversibility:
other: marked necrosis rounded by significant erythema, not reversible
Remarks on result:
other: scores not given
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritant / corrosive response data:
see table
Other effects:
no further data

Any other information on results incl. tables

no further data

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
corrosive
Executive summary:

Undiluted test substance was applied to the back of rabbits for up to 20 hours and post exposure observed for up to 8 days. the testsubstance caused necrosis which was noted already 24 hours after an exposure time of 1 min (BASF 1970)