Registration Dossier
Registration Dossier
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EC number: 203-629-0 | CAS number: 108-91-8
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- other: relationship cyclohexylamine and cyclamate
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The metabolism of cyclamate to cyclohexylamine in humans during long-term administration
- Author:
- Renwick AG et al
- Year:
- 2 004
- Bibliographic source:
- Toxicol appl Pharmacol 196, 367-380
- Reference Type:
- publication
- Title:
- In vivo conversion of C-labelled cyclamate to cyclohexylamine
- Author:
- Parosky L et al
- Year:
- 1 971
- Bibliographic source:
- J Pharmacol Sci 60, 1341-2343
- Reference Type:
- publication
- Title:
- The metabolism of cyclamates in rats
- Author:
- Wallace WC, Kethco EJ, Brouwer EA
- Year:
- 1 970
- Bibliographic source:
- J Pharmacol Exp Toxicol 175, 325-330
- Reference Type:
- publication
- Title:
- a 7-month study of ingestion of socium cyclamate by human volunteers
- Author:
- Wills JH, Serrone DM, Coulston F
- Year:
- 1 981
- Bibliographic source:
- Regul toxicol Oharmacol 1, 163-176
- Reference Type:
- publication
- Title:
- Beitrag zur hygienischen Beurteilung von Cyclamat
- Author:
- Wolf A et al
- Year:
- 1 971
- Bibliographic source:
- Die Nahrung 15, 363.366
- Reference Type:
- publication
- Title:
- Long-term toxicits and carcinogenicity study of cyclamate in nonhuman primates
- Author:
- Takayama S, Renwick AG, Johansson SL, Thorgeirsson UP, Tsutsumi M, Dalgard DW, Sieber SM
- Year:
- 2 000
- Bibliographic source:
- Tox Sci 53, 33-39
- Reference Type:
- publication
- Title:
- Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans
- Author:
- Serra-Majem L et al
- Year:
- 2 003
- Bibliographic source:
- Food Add Contam 20, 1097-1194
- Reference Type:
- publication
- Title:
- Possible mutagenic activity of saccharin
- Author:
- Renner HW
- Year:
- 1 979
- Bibliographic source:
- Experientia 35, 1364-1365
- Reference Type:
- publication
- Title:
- Excretion of cyclohexylamine, a metabolite of cyclamate in human urine
- Author:
- Asahina M et al
- Year:
- 1 971
- Bibliographic source:
- Chem Pharm Bull 19, 628-632
- Reference Type:
- publication
- Title:
- Entero-bacterial formation of cyclohexylamine in rats ingesting cyclamate
- Author:
- Bickel MH et al
- Year:
- 1 974
- Bibliographic source:
- Xenobiotical 4, 425-439
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
