Cyclohexylamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: individual doses and animal data are not shown

Data source

Reference

Reference Type:

publication

Title:

Range-finding Toxicity data: List VII

Author:

Smyth jr HF, Carpenter ChP, Weil CS, Pozzani UC, Striegel JA, Nycum JS

Year:

1969

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 30, 470-476

Materials and methods

Principles of method if other than guideline:

Different doses of test substance was applied to the shaved skin of male rabbits for 24 hours and observed for mortality for 14 days.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Cyclohexylamine

EC Number:

203-629-0

EC Name:

Cyclohexylamine

Cas Number:

108-91-8

Molecular formula:

C6H13N

IUPAC Name:

cyclohexanamine

Details on test material:

no further data

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

initial bod weight : 2.5 to 3.5 kg

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Different doses of test substance were applied to the shaved skin of male rabbits for 24 hours. The testsubstance is retained beneath an impervious plasma film.

Duration of exposure:

24 hours

Doses:

individual doses are not given

No. of animals per sex per dose:

4

Control animals:

no

Details on study design:

Different doses of test substance were applied to the shaved skin of male rabbits for 24 hours. The testsubstance is retained beneath an impervious plasma film. The animals are immobilized during the24 hour period, after which the film is removed. the rabbits are caged for the subsequent 14 day observation period. Based upon mortality during a 14-day observation period the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil

Statistics:

the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 275 mg/kg bw

95% CL:

>= 208 - <= 372

Mortality:

Based upon mortality during a 14-day observation period the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil (no further data)

Clinical signs:

other: no data

Gross pathology:

no data

Other findings:

no data

Any other information on results incl. tables

Different doses of cyclohexylamine were applied to the shaved skin of male rabbits for 24 hours under occlusive conditions. the LD50 is 275 mg/kg bw (Smyth 1969)