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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation; no detailed information on testing atmosphere and/or

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
Method: rats were exposed to an atmosphere which was satified with vapour at 20°C for 10 min and for 30 min
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexylamine
EC Number:
203-629-0
EC Name:
Cyclohexylamine
Cas Number:
108-91-8
Molecular formula:
C6H13N
IUPAC Name:
cyclohexanamine
Details on test material:
IUCLID4 Test substance: other TS: as prescribed by chapter 1 BASF AG

Test animals

Species:
rat

Administration / exposure

Details on inhalation exposure:
rats were exposed to an atmosphere which was satisfied with vapour at 20°C for 10 min and for 30 min
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 10 - <= 30 min
Concentrations:
a satisfied vapour atmosphere
No. of animals per sex per dose:
no data
Control animals:
no
Details on study design:
rats were exposed to an atmosphere which was satisfied with vapour at 20°C for 10 min (12 rats) and for 30 min (6 rats). To reach a satisfied atmosphere air was piped through a of 5 cm layer of testsubstance at 20 °C
Statistics:
no data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: satisfied vapour atmosphere
Based on:
other: satisfied vapour atmosphere
Exp. duration:
10 min
Remarks on result:
other: mortality 0/12
Sex:
not specified
Dose descriptor:
other: mortality
Based on:
other: satisfied vapour atmosphere
Exp. duration:
30 min
Remarks on result:
other: mortality: 3/6
Mortality:
exposure time: 10 min: 0/12
exposure time 30 min: 3/6
Clinical signs:
other: all animals tried to escape, marked irritations of the mucous membranes, dyspnea (gasping), bloody crusted eyes and nose
Body weight:
no data
Gross pathology:
bloody crusted snouts
Other findings:
no further data

Any other information on results incl. tables

no further data

Applicant's summary and conclusion

Executive summary:

Exposusre of 12 rats for 10 min against a vapour saturated test atmosphere caused no death; exposure for 30 min to 6 rats caused the death of 3/6 rats. Clinical signs were displayed of all animals and included marked irritations of the mucous membranes, dyspnea and gasping (BASF 1970)