Registration Dossier
Registration Dossier
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EC number: 204-371-1 | CAS number: 120-12-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Method: standard method
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Anthracene
- EC Number:
- 204-371-1
- EC Name:
- Anthracene
- Cas Number:
- 120-12-7
- Molecular formula:
- C14H10
- IUPAC Name:
- anthracene
- Details on test material:
- purity: 'Anthrazen reinst'
Product No. 110 147
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Schering AG, Berlin
- Age at study initiation:
- Weight at study initiation: 105 - 115 (m); 90 - 100 (f)
- Fasting period before study: 16 h
- Housing: conventional, air-conditioned
- Diet (e.g. ad libitum):
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +-1 °C
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 40 % anthracene
- Concentration CMC: 0.5 % in water
- Amount of vehicle (if gavage): 60 %
- Justification for choice of vehicle: achieving fine distribution in an aqueous medium
MAXIMUM DOSE VOLUME APPLIED: approx. 40 mL/kg bw (calculated from data)
- Doses:
- 16 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: rough fur, paleness of extrimities, and hunched posture
- Gross pathology:
- low- to moderate-grade hyperemia of the lungs and moderate-grade hyperemia of the livers
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
