Registration Dossier
Registration Dossier
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EC number: 204-371-1 | CAS number: 120-12-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Bioalkylation and biooxidation of anthracene, in vitro and in vivo.
- Author:
- Myers SR, Blake JW, Flesher JW
- Year:
- 1 988
- Bibliographic source:
- Biochem. Biophys. Res. Comm. 151, 1441-1445
Materials and methods
- Objective of study:
- metabolism
- GLP compliance:
- no
Test material
- Reference substance name:
- Anthracene
- EC Number:
- 204-371-1
- EC Name:
- Anthracene
- Cas Number:
- 120-12-7
- Molecular formula:
- C14H10
- IUPAC Name:
- anthracene
- Details on test material:
- purity: no impurities detected (HPLC, GC/MS)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- subcutaneous
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
Any other information on results incl. tables
Anthracene is metabolized in vivo (Sprague-Dawley rats, m;
subcutaneous tissue) and in vitro (rat liver cytosol
preparations) to 9-methyl and 9,10-dimethylanthracene.
These compounds are further decomposed to
9-hydroxymethylanthracene and
9-hydroxymethyl-10-methylanthracene as well as
9-formylanthracene and dihydroxymethylanthracene.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
