Registration Dossier
Registration Dossier
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EC number: 204-371-1 | CAS number: 120-12-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Aug. 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method: standard
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Anthracene
- EC Number:
- 204-371-1
- EC Name:
- Anthracene
- Cas Number:
- 120-12-7
- Molecular formula:
- C14H10
- IUPAC Name:
- anthracene
- Details on test material:
- purity: 'Anthrazen reinst'
Product No. 110.147
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. A. Ivanovas, Kisslegg/Germany
- Age at study initiation:
- Weight at study initiation: 220 - 245 (m); 210 - 250 (f)
- Fasting period before study: approx. 16 h, new feed 4 h post-application
- Housing: single
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +-1
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 5 x 7.5 cm
- skin shaved
- Type of wrap if used: aluminum foil covered with adhesive tape round the trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): luke-warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1320 mg in 3.3 mL PEG/kg bw (maximum volume technically applicable)
- concentration in vehicle: approx. 25 % (w/v) (maximum amount technically applicable)
- For solids, paste formed: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): 3.3 mL/kg bw - Duration of exposure:
- 24 h
- Doses:
- 1320 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- not applicable
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 1 320 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: none, no systemic effects
- Gross pathology:
- no particular findings
- Other findings:
- no local effects
Applicant's summary and conclusion
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