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EC number: 421-950-6 | CAS number: 187674-70-0 Y-104
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 hour EC50 > 100 mg/L in freshwater Daphnia magna, OECD 202, EU Method C2, Thomas 1996
Key value for chemical safety assessment
Additional information
The acute toxicity potential of the test material to aquatic invertebrates was determined in the key study by Thomas (1996). The study was conducted under GLP conditions and in accordance with the standardised guidelines OECD 202 and EU method C2, using Daphnia magna as the test organism. Based on the principles for assessing data quality defined by Klimisch et al. (1997), the study was assigned a reliability score of 1.
A preliminary test was conducted at nominal concentrations of 0 (M4 dilution water control), 0.1, 1, 10 and 100 mg/L for 48 hours under static conditions. Twenty daphnids were exposed to each concentration. Immobilisation at each concentration was recorded at 0, 24 and 48 hours.
No immobilisation occurred in any dose group. Since the test material was found not to be toxic at the nominal limit concentration of 100 mg/L, a definitive study was deemed unnecessary and samples of the control and 100 mg/L solutions were analysed to verify the concentration of the test material at 0, 24 and 48 hours during the test. As measured concentrations were >80 % of the nominal concentrations, all results were based on nominal values.
Under the conditions of the test, no immobilisation was recorded in any of the dose groups over the 48 hour observation period. The EC50 is therefore is considered to be > 100 mg/L (maximum concentration tested).
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