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EC number: 217-315-6 | CAS number: 1809-14-9
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From March 29th to April 20th, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- February 24th, 1987
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Dioctyl phosphonate
- EC Number:
- 217-315-6
- EC Name:
- Dioctyl phosphonate
- Cas Number:
- 1809-14-9
- Molecular formula:
- C16H35O3P
- IUPAC Name:
- dioctyl phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAI f (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CIBA-GEIGY Limited, Animal Production, 4332 Stein/Switzerland.
- Weight at study initiation: 201-258 g.
- Housing: individually in Macrolon cages type 3, with the standardized soft wood bedding.
- Diet: rat chow (NAFAG 890 Tox, NAFAG, Gossau/SG, Switzerland), ad libitum.
- Water: ad libitum.
- Acclimation period: 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 2 °C;
- Humidity: 55 ± 10 %;
- Air changes: 15 per hour;
- Photoperiod: 12 hour/day light cycle.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back;
- % coverage: about 10 %.
- Pretreatment: shaving of the treated area with an electric clipper approximately 24 hours before treatment;
- Type of wrap if used: gauze-lined semiocclusive dressing fastened around the trunk with an adhesive elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: yes, with lukewarm water;
- Time after start of exposure: 24 hours.
TEST MATERIAL
- Amount applied: 2000 mg/kg bw (2 ml/kg bw);
- Vehicle: none, liquid substance used undiluted. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 rats (5 males and 5 females)
- Control animals:
- not required
- Details on study design:
- - Frequency of application: one single dose.
- Duration of observation period following administration: 14 days for the females and 22 days for the males.
- Frequency of mortality observations: daily, a.m. and p.m. on working days, a.m. on weekend days.
- Frequency of signs and symptoms observations: daily.
- Necropsy of survivors performed: yes.
- Other examinations performed: Body weight: immediately before application and on days 7 and 14 (additionally on day 22 in case of the males).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: In the females erythema, scaling and necrosis at the application site were observed; they recovered within 13 days. In the males edema at the application site was noticed until day 4, erythema and necrosis were observed until day 8, from day 9 until day 2
- Gross pathology:
- At autopsy, no deviations from normal organs morphology were found.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified for acute dermal toxicity according to the CLP Regulation (EC n.1272/2008).
- Conclusions:
- LD50 rat dermal route (males/females) > 2000 mg/kg bw and no classification for acute dermal toxicity is required according to the CLP Regulation (EC n.1272/2008).
- Executive summary:
The substance was tested for acute dermal toxicity on rats according to OECD TG 402.
Upon an acute dermal administration and 14 to 22 day post-treatment observation period, the LD50 in rats of both sexes is greater than 2000 mg/kg bw.
Erythema, scaling and necrosis at the application site were observed. The females recovered within 13, the males within 9 days from necrosis. In the latters, scurf was seen until day 21.
At autopsy, no deviations from normal morphology were found.
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