Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-315-6 | CAS number: 1809-14-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Exploratory acute oral study on rats: three males and three females were dosed with 200 mg/kg bw and 2000 mg/kg bw of the test substance. Observation period not specified.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dioctyl phosphonate
- EC Number:
- 217-315-6
- EC Name:
- Dioctyl phosphonate
- Cas Number:
- 1809-14-9
- Molecular formula:
- C16H35O3P
- IUPAC Name:
- dioctyl phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 200 mg/kg bw and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 males and 3 females for each dose.
- Control animals:
- not specified
- Details on study design:
- - Necropsy of survivors performed: yes
- Other examinations performed: clinical signs observation.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at both doses (200 mg/kg bw and 2000 mg/kg bw).
- Clinical signs:
- other: Piloerection, hunched posture and dyspnea were seen; additionally, reduced locomotor activity was observed in all animals. The animals recovered within 3 to 6 days.
- Gross pathology:
- At autopsy, no deviations from normal morphology were found.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified for acute oral toxicity according to the CLP Regulation (EC n.1272/2008).
- Conclusions:
- LD50 rat oral route (males/females) > 2000 mg/kg bw and no classification for acute oral toxicity is required according to the CLP Regulation (EC n.1272/2008).
- Executive summary:
The exploratory acute oral LD50 for the substance administered by gavage to the young albino rat of both sexes was estimated to be greater than 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
