Registration Dossier
Registration Dossier
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EC number: 217-315-6 | CAS number: 1809-14-9
Endpoint summary
Administrative data
Description of key information
Dioctyl phosphonate is not skin sensitiser.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Dioctyl phosphonate was tested in "Lusens test" on the basis to the protocol “LuSens Assay” provided by BASF SE and the OECD Guideline 442D. This test investigates the Key Event 2 (i.e. Keratinocyte response) in the skin sensitisation pathway. In all tested concentrations of the test item for both experiments no substantial and reproducible dose dependent increase of luciferase induction above 1.5 was measured. In conclusion Dioctyl phosphonate is not considered as a potential sensitizer.
Combining the result of LuSens Test with consideration on physico-chemical properties of the test item, QSAR predictions, information from similar substances, animal studies and human data available , it is possible to conclude that Dioctyl phosphonate is not skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the CLP Regulation (EC. n.1272/2008), Skin sensitiser means a substance that may trigger an allergic response following skin contact. The skin sensitisation potential of Dioctyl phosphonate was investigated according to EU Regulation 2016/1688 - updated regarding skin sensitisation requirement of annex VII of the REACH regulation (EC. n. 1907/2006) in force since 11th October 2016. The biological mechanisms of skin sensitisation is a stepwise mechanism (Adverse Outcome Pathway -AOP) that follows these starting key events: (a) molecular interaction with skin proteins; (b) inflammatory response in keratinocytes; (c) activation of dendritic cells. LuSens test investigates activation of keratinocytes. Combining the result of LuSens Test with consideration on physico-chemical properties of the test item, QSAR predictions, information from similar substances, animal studies and human data available, it is possible to conclude thatthat Dioctyl phosphonate is not skin sensitiser according to the CLP Regulation (EC. n.1272/2008),
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