Registration Dossier
Registration Dossier
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EC number: 217-315-6 | CAS number: 1809-14-9
Endpoint summary
Administrative data
Description of key information
LD50 rat oral route (males/females) > 2000 mg/kg bw
LD50 rat dermal route (males/females) > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Exploratory acute oral toxicity study.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Study conducted according to internationally accepted testing guidelines.
Additional information
An explorative acute oral toxicity test was performed on Dioctyl phosphonate and the result was LD50 rat oral route (males/females) > 2000 mg/kg bw. Even though only limited details were reported in this study, its result is of none concern. No concern regarding the oral toxicity of the substance was confirmed also by Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test according to OECD TG 422 on Dioctyl phosphonate. In fact, the substance is not classified neither for acute oral toxicity nor for repeated oral toxicity according to the CLP Regulation (EC n.1272/2008).
An acute dermal toxicity test according to OECD TG 402 was performed on the substance and the result of this study was LD50 rat dermal route (males/females)> 2000 mg/kg bw .
Testing by inhalation route is not appropriate for Dioctyl phosphonate because the exposure of human via inhalation is unlike taking in account its low vapour pressure.
Justification for classification or non-classification
Based on LD50 rat oral route and dermal route > 2000 mg/kg bw and according to the CLP Regulation (EC n.1272/2008), nor classification regarding acute oral toxicity neither classification regarding acute dermal toxicity is required for Dioctyl phosphonate.
There is no concern regarding inhalation route because the exposure of human via inhalation is unlike taking in account the low vapour pressure of the substance.
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