Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Comparison of Behavioral Teratogenic Effects of Ethanol an N-Propanol administered by Inhalation to Rats
Author:
Nelson B.K., Brightwell W.S., Burg J.R
Year:
1985
Bibliographic source:
Neurobehavioral Toxicology and Teratology, Vol. 7, 779-783
Reference Type:
publication
Title:
Behavioral Teratology Investigation of 1-Propanol Administered by Inhalation to Rats
Author:
Nelson B.K., Brightwell W.S., Taylor B.J., Khan A., Burg J.R., Krieg E.F., Massari V.J.
Year:
1989
Bibliographic source:
Neurotoxicol.Teratol. 11, 153-159

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: other
Principles of method if other than guideline:
Male animals were treated for 42 days, then mated with untreated virgin females . Resulting pregnant females were sham exposed on gestation days 1-19 (experiment 1). Another group of untreated males and females were mated. Resulting pregnant females were then exposed to the test substance on gestation days 1-19 (experiment 2).
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Propan-1-ol
EC Number:
200-746-9
EC Name:
Propan-1-ol
Cas Number:
71-23-8
Molecular formula:
C3H8O
IUPAC Name:
Propan-1-ol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure (if applicable):
whole body
Vehicle:
air
Duration of treatment / exposure:
Experiment 1
- Males : 6 weeks premating
- Females: sham exposed


Experiment 2
- Males: sham exposed
- Females: day 1-19 of gestation
Frequency of treatment:
7 h/day. 7 days/week.
Doses / concentrationsopen allclose all
Dose / conc.:
0 mg/m³ air (nominal)
Dose / conc.:
8 730 mg/m³ air (nominal)
Dose / conc.:
17 460 mg/m³ air (nominal)
Dose / conc.:
24 940 mg/m³ air (nominal)
No. of animals per sex per dose:
female 15; male 18

Results and discussion

Results: P0 (first parental generation)

Reproductive function / performance (P0)

Reproductive function: oestrous cycle:
no effects observed

Effect levels (P0)

Key result
Dose descriptor:
NOAEC
Effect level:
ca. 8 730 mg/m³ air (nominal)
Based on:
test mat.
Sex:
male
Basis for effect level:
other: Based on the reversible fertility effects

Results: F1 generation

Effect levels (F1)

Key result
Dose descriptor:
NOAEC
Generation:
F1
Effect level:
ca. 3 500 ppm (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
clinical signs

Overall reproductive toxicity

Key result
Reproductive effects observed:
no
Lowest effective dose / conc.:
8 730 mg/m³ air
Treatment related:
no

Applicant's summary and conclusion