Registration Dossier
Registration Dossier
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EC number: 245-711-9 | CAS number: 23519-77-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 103 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECETOC technical report no. 86
- Overall assessment factor (AF):
- 6
- Dose descriptor starting point:
- NOAEC
- Value:
- 1 230 mg/m³
- Explanation for the modification of the dose descriptor starting point:
NOAEC from rat subchronic inhlation study = 1230 mg/m3 (Bushy run 1992, European Union Risk Assessment Report, propan-1-ol, 2008)
Modification of the dose descriptor according to ECHA Guidance R.8
Corrected inhalatory NOAEC = inhalatory NOAEC * (exp.time rat/exp.time worker) * (ABS rat/ABS human) * (sRVhuman 8h/wRV)
ABS – absorption (assumed 100% in human and in experimental animamals)
sRVhuman – respiratory volume under standard conditions
wRV – respiratory volume light activity for worker
Corrected NOAEC = 1230 mg/m3 * ( 6 h/d / 8 h/d) * (100/100) * (6.7 m3/ 10 m3) = 618.1 mg/m3
Assessment factors – based on ECETOC (2003) technical report no. 86
Intraspecies difference for worker = 3
exposure duration subchronic to chronic = 2
Overall AF = 3*2 = 6
DNEL worker systemic effects by inhalation = 618.1 / 6 = 103 mg/m3
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
The substance is classified for eye damage category 1 and skin irritation category 2 and STOT SE 3 (drowsiness); moderate hazard is assigned according to ECHA CSA guidance Part E Table E 3-1. Risk characterisation is conducted qualitatively.
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
None.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
None.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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