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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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activated sludge respiration inhibition testing
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
Justification for type of information:
The target substance is hydrolytically unstable with hydrolysis half-life less than 5 minute. The hydrolysis products include 1-propanol and hydrated zirconium dioxide. The ecotoxicity data of the organic parts have been well-investigated and used for read-across.
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
according to guideline
other: other
Principles of method if other than guideline:
Serum bottle test (closed system)
GLP compliance:
not specified
Analytical monitoring:
Test organisms (species):
activated sludge
Test type:
Water media type:
Limit test:
Total exposure duration:
12 h
Key result
12 h
Dose descriptor:
Effect conc.:
ca. 9 600 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Validity criteria fulfilled:

Description of key information

Key value for chemical safety assessment

EC50 for microorganisms:
9 600 mg/L

Additional information

No studies were conducted on the target substance, Zirconium tetrapropanolate. As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance.

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) zirconium dioxide and well-evaluated organic substances – 1-propanol.

The zirconium dioxide is not considered further in this report as aquatic toxicity assessments do not apply.

Toxicity of 1-propanol to tested on activated sludge indicated EC50 (12h) of 9600 mg/l (Blum and Speece, 1991) The value was used for CSA.