Registration Dossier
Registration Dossier
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EC number: 245-711-9 | CAS number: 23519-77-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Development and Validation of an Alternative Dermal Sensitization Test : The Mouse Ear Swelling Test (MEST)
- Author:
- Gad S.C., Dunn B.J., Dobbs D.W., Reilly C., Walsh R.D.
- Year:
- 1 986
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 84, 93-114.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- existing study available from publication
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- Propan-1-ol
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: intradermal and epicutaneous occlusive
- Vehicle:
- not specified
- Concentration / amount:
- 100%
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- not specified
- Concentration / amount:
- 100%
- No. of animals per dose:
- Test group: 15
control group: 6 - Positive control substance(s):
- yes
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 15
- Clinical observations:
- no data
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 6
- Clinical observations:
- no data
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Dose level:
- 100%
- No. with + reactions:
- 15
- Total no. in group:
- 15
- Clinical observations:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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