Registration Dossier
Registration Dossier
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EC number: 245-711-9 | CAS number: 23519-77-9
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- authority reviewed.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- EU Risk Assessment Report, CAS No. 71-23-8: Propan-1-ol, Vol. 82
- Author:
- European Chemicals Bureau
- Year:
- 2 008
- Bibliographic source:
- EU Risk Assessment Report
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Principles of method if other than guideline:
- Study followed intent of OECD 412 with only 9 exposures in 12 days.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- Propan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- 6 hr/day, 4 days/week up to 2 weeks. (9 exposure days)
Doses / concentrationsopen allclose all
- Dose / conc.:
- 246 mg/m³ air
- Dose / conc.:
- 1 230 mg/m³ air
- Dose / conc.:
- 2 460 mg/m³ air
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- slightly swollen periocular tissue, and minimal perinasal and periocular encrustations in the 1000 ppm (2460 mg/m3) exposure concentration group
Effect levels
- Key result
- Dose descriptor:
- NOAEC
- Effect level:
- ca. 1 230 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
