Registration Dossier
Registration Dossier
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EC number: 245-711-9 | CAS number: 23519-77-9
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- authority reviewed.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- EU Risk Assessment Report, CAS No. 71-23-8: Propan-1-ol, Vol. 82
- Author:
- European Chemicals Bureau
- Year:
- 2 008
- Bibliographic source:
- EU Risk Assessment Report
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Principles of method if other than guideline:
- Study followed intent of OECD 412 with only 9 exposures in 12 days.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- Propan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- 6 hr/day, 4 days/week up to 2 weeks. (9 exposure days)
Doses / concentrationsopen allclose all
- Dose / conc.:
- 246 mg/m³ air
- Dose / conc.:
- 1 230 mg/m³ air
- Dose / conc.:
- 2 460 mg/m³ air
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- slightly swollen periocular tissue, and minimal perinasal and periocular encrustations in the 1000 ppm (2460 mg/m3) exposure concentration group
Effect levels
- Key result
- Dose descriptor:
- NOAEC
- Effect level:
- ca. 1 230 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
Applicant's summary and conclusion
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