Registration Dossier
Registration Dossier
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EC number: 245-711-9 | CAS number: 23519-77-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- 1-propanol is the main hydrolysis prodcuts of the target substance. Properties of the the hydrolysis substance are used for read-across.
Data source
Reference
- Reference Type:
- publication
- Title:
- A Comparison of the Toxicity of Some Allyl, Propenyl, and Propyl Compounds in the Rat.
- Author:
- Taylor J.M., Jenner P.M., Jones W.I.
- Year:
- 1 964
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 6, 378-387.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other
- Principles of method if other than guideline:
- Group of 5 male and 5 female rats (180-350 g) per dose level were administered the test substance by stomach tube. The rats were fasted 18 hr before administration. The rats were observed until the survivors had returned to normal in appearance and weight.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- Propan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 6 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality occured within 2 - 18 hr after administration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 on rats was 6500 mg/kg bw. GHS criteria was not met for acute oral toxicity.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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