Registration Dossier
Registration Dossier
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EC number: 203-916-0 | CAS number: 111-86-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC = 32 mg/L (OECD 301A; BASF AG, 1997)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 32 mg/L
Additional information
This endpoint is sufficiently covered by the data on biodegradability (see section 5.2).
The inhibitory effect of octylamine on activated sludge from a wwtp treating predominantely domestic sewage was investigated during a ready biodegradability study (BASF AG, 1997; Report No. BASF96/0345/21/1). At the tested concentration of 32 mg/L no inhibitory effect was observed. Therefore it can be concluded that the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
This is supported by growth inhibition studies using the ciliate Tetrahymena pyriformis (Schultz et al., 1991; 1997; 2006), which is a relevant organsim in STPs (ECHA guidance documents R.7b, R.10). EC50 -values (48 h; inhibition of growth) of 40.4 mg/L, 31.8 mg/L and 57.6 mg/L, respectively, were determined in these studies. For derivation of PNEC_STP, an assessment factor of 10 is applied to either of the following results (R.10): a NOEC derived from a ready biodegradability test (key study); an EC50 derived from a test with Tetrahymena. Therefore, an essentially equal PNEC would be derived based on the data on Tetrahymena compared to the NOEC from the ready biodegradabilit test. As such, the data on Tetrahymena strongly support the result from the key study.
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