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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions ( observation period 7 days; limited documentation, i.e. no details reported (location; size of treated area; exposure duration; washing etc.)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1985

Materials and methods

Principles of method if other than guideline:
Method: three dose levels tested, observation period 7 days; however, no details reported (location; size of treated area; exposure duration; washing)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octylamine
EC Number:
203-916-0
EC Name:
Octylamine
Cas Number:
111-86-4
Molecular formula:
C8H19N
IUPAC Name:
octan-1-amine
Details on test material:
1-Octanamine, not further specified
- Name of test material (as cited in study report): C-903

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Acclimation period: 14 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 60-85°F

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: none
Details on dermal exposure:
Project No. 6006-85
Protocal No. C22/AO-MSDS
Duration of exposure:
no data
Doses:
200, 2000, and 3000 mg/kg bw
No. of animals per sex per dose:
4
Control animals:
no
Details on study design:
- Duration of observation period following administration: 17 days
Statistics:
none

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD0
Effect level:
200 mg/kg bw
Sex:
not specified
Dose descriptor:
LD100
Effect level:
2 000 mg/kg bw
Mortality:
Within 7 days no deaths (0/4) at 200 mg/kg bw; all animals dead at 2000 mg/kg bw (4/4, within 2 days) and at 3000 mg/kg bw (4/4, within 1 day)
Clinical signs:
other: At 200 mg/kg, dermal necrosis At the high doses, hypoactivity and prostration prior to death

Any other information on results incl. tables


MORTALITY:

 200 mg/kg bw: 0/4 animals
2000 mg/kg bw: 4/4 animals
3000 mg/kg bw: 4/4 animals
  
CLINICAL SIGNS:
At 200 mg/kg, dermal necrosis
At the high doses, hypoactivity and prostration

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Dermal LD50 (rabbit): 200 mg/kg bw
Executive summary:

The dermal toxicity of n-octylamine was tested in rabbits (4 animals per dose) at 200, 2000, and 3000 mg/kg bw. The observation period was 7 days, other methodological details were not reported. However, the study is regarded to be reliable with restrictions.

All animals at 3000 and 2000 mg/kg bw died within one or two days, respectively. There were no deaths within 7 days after treatment in rabbits receiving 200 mg/kg bw but dermal necrosis at the test sites. The LD50 (dermal, rabbit) was therefore higher than 200 mg/kg bw and less than 2000 mg/kg bw (Biodynamics, 1985).