Registration Dossier
Registration Dossier
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EC number: 226-218-8 | CAS number: 5329-14-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented, peer-reviewed research study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII
- Author:
- Smyth HF jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA & Nycum JS
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1969, Sep-Oct; 30(5):470-6
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was performed as part of a series of 'range-finding' tests performed with a large number of industrial chemicals. The protocol for acute oral toxicity is broadly similar to OECD 401 in that groups of rats were intubated with a single dose of the test material and observed for 14 days.
- GLP compliance:
- no
- Remarks:
- Pre-GLP
Test material
- Reference substance name:
- Sulphuric acid
- EC Number:
- 231-639-5
- EC Name:
- Sulphuric acid
- Cas Number:
- 7664-93-9
- Molecular formula:
- H2O4S
- IUPAC Name:
- sulfuric acid
- Test material form:
- other: Presumed to be liquid
- Details on test material:
- 95-98% pure (reagent grade sulphuric acid)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- other: gastric intubation
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Not given
- No. of animals per sex per dose:
- 5 females in all were dosed.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 140 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Effect ranged from 1540 to 2990 mg/kgbw
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study sulphuric acid demonstrated a low acute oral toxicity when gastric intubation was used as the method of administration. The LD50 by oral administration was calculated to be 2140 mg/kg body weight.
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