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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Short description of key information:
in vitro:
- The test item 2,4,5-Trichloranilin did not induce gene mutations by base pair changes in the genome of the strains used in the Ames test (i.e. S. typhimurium TA 1535, TA 1537, TA 98 and TA 100).
- The test material 2,4,5-Trichloranilin, did not induce significant changes in the nuclear labeling of rat primary hepatocytes in an UDS test for an applied concentration range of 25µg/ml to 0.501 µg/ml.
In vivo:
No indications of clastogenic effect of 7500 mg/kg bw of 2,4,5 -Trochloroaniline per os were found in the micronucleus test in the mouse (i.e. in a somatictest system in vivo).

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification