Registration Dossier
Registration Dossier
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EC number: 211-254-9 | CAS number: 636-30-6
Endpoint summary
Administrative data
Description of key information
Based on the results of a study on the acute oral toxicity the (LD50) of 2,4,5 -Trichloranilin was determined to be 2093 mg/kg bw (1816- 2413 mg/kg bw) for the male rat.
Based on the results of a second acute toxicity study performed with male and female rats the acute oral toxicity (LD50) of 2,4,5 -Trichloranilin was determined to be greater than 5000 mg/kg bw for male and female rats.
The results of the acute oral toxicity studies in cats showed the formation of increasing Met-hemoglobin values and Heinz-bodies after a single oral application of 10, 20 and 200mg/kg bw in two independent trials, with one cat (i.e. 10mg/kg bw) and in 2 cats per dose (i.e. 20 and 200mg/kg bw).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 1 000 mg/kg bw
Additional information
Oral Toxicity: The LD50 was >2000 mg/kg in all studies in rats and even exceeded 5000 mg/kg bw in the one valid study.
Dermal toxicity: The value states the NOEL. The LD 50 was above 2500 mg/kg bw.
Justification for classification or non-classification
No adverse effects were observed at reasonably achievable doses relevant for human exposure after oral or dermal exposure in rats. Nevertheless, the material is classified according to annex I to Guideline 67/548 EWG index # 612 -010 -00 -8 (Chloroanilines)
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