Registration Dossier
Registration Dossier
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EC number: 211-254-9 | CAS number: 636-30-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study complies to general scientific principles; pre-dates GLP regulations, short report, few methodological details
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP-implementation
Test material
- Reference substance name:
- 2,4,5-trichloroaniline
- EC Number:
- 211-254-9
- EC Name:
- 2,4,5-trichloroaniline
- Cas Number:
- 636-30-6
- Molecular formula:
- C6H4Cl3N
- IUPAC Name:
- 2,4,5-trichloroaniline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - Animals : 3 males, singlly caged
- Environment: 19-21 C; 40-50 % humidity; 12 h light-12 h dark
- Feed: Ssniff K4
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- 500 mg per site (6.25 cm²)
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No local findings at all
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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