Registration Dossier
Registration Dossier
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EC number: 211-254-9 | CAS number: 636-30-6
Specific investigations: other studies
Administrative data
- Endpoint:
- mechanistic studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study complies to general scientific principles; short report, few methodological details; relevance to safety evaluation not clear
Data source
Reference
- Reference Type:
- publication
- Title:
- Characterization of the activation of rat liver Glutathione-S-transferases by nonsubstrate ligands
- Author:
- Vessey, D.A.; Boyer, T.D.
- Year:
- 1 988
- Bibliographic source:
- Toxcol. Appl. Pharmacol. 93: 275-280 (1988)
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Enzyme activity was determined in the presence and absence of a number of activators/inhibitors in vitro
- GLP compliance:
- no
- Remarks:
- not required
- Type of method:
- in vitro
Test material
- Reference substance name:
- 2,4,5-trichloroaniline
- EC Number:
- 211-254-9
- EC Name:
- 2,4,5-trichloroaniline
- Cas Number:
- 636-30-6
- Molecular formula:
- C6H4Cl3N
- IUPAC Name:
- 2,4,5-trichloroaniline
Constituent 1
Results and discussion
- Details on results:
- 2,4,5 trichloroaniline activated HGSH-transferase from rat liver, sub-type YcYc, by a factor of 1.65 in this in vitro system.
Applicant's summary and conclusion
- Conclusions:
- 2,4,5 trichloroaniline activated HGSH-transferase from rat liver, sub-type YcYc, by a factor of 1.65 in this in vitro system. The relevance of this finding for safety evaluation is unclear.
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